Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power
This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds. tm,cc,jp
Upon binding, a "closed" conformation is adopted, where C-terminal domains (C2F, C2G) rearrange. 3. Key Findings in Synaptic Transmission Ca 2+raised to the 2 plus power Key Findings in Synaptic Transmission Ca 2+raised to
The study highlights that membrane binding involves a cooperative effort of multiple domains. Role: Otoferlin acts as a key Ca 2+raised
Structure and function of otoferlin, a synaptic protein of ... - PMC
Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission,
This guide focuses on the molecular mechanism of otoferlin-mediated vesicle docking and Ca 2+raised to the 2 plus power sensing in inner hair cells (IHCs). Role: Otoferlin acts as a key Ca 2+raised to the 2 plus power sensor for synaptic vesicle fusion in auditory IHCs.