: Rhimes described the episode as the moment Meredith evolved from a "dark and twisty" girl into an "extraordinary" woman capable of choosing happiness.
In , the Season 5, Episode 22 milestone titled " What a Difference a Day Makes " is a landmark 100th episode that originally aired on May 7, 2009. It is widely celebrated for its emotional depth, shifting from a planned grand wedding for Meredith and Derek to a poignant ceremony for Izzie Stevens and Alex Karev. The Unexpected Wedding [S5E22] What a Difference a Day Makes
: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. : Rhimes described the episode as the moment
While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation. The Unexpected Wedding : To promote the 100th