The episode sees the main cast temporarily separate. Kurapika and Melody leave to continue their work with the Nostrade family, and Leorio departs to pursue his medical studies.
In the , Episode 60 ("Assassins x Chrollo x Prophecy") is completely different, focusing on Gon and Killua's escape from Nobunaga during the Yorknew arc. Hunter X Hunter Episode 60
Reviewers from Meeping Anime note a significant shift as the "old" Yorknew crew exits and the "new" RPG-style adventure begins. The episode sees the main cast temporarily separate