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Understanding and Interpreting Serum Protein Electrophoresis

This guide outlines how to interpret Serum Protein Electrophoresis (SPEP) results, which separate blood proteins into specific fractions to help diagnose conditions like multiple myeloma, liver disease, or inflammation.

: Liver disease, kidney loss (nephrotic syndrome), or malnutrition. Increased : Dehydration. Alpha-1 Alpha-1 antitrypsin Increased : Acute inflammation. Alpha-2 Haptoglobin, Alpha-2 macroglobulin Increased : Acute phase reaction or nephrotic syndrome. Beta Transferrin, Complement Increased : Iron deficiency or high cholesterol. Two peaks ( ) are visible in capillary tests. Gamma Immunoglobulins (Antibodies)

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