If the game crashes on launch or during scene transitions, try unticking DirectX 11 in the game's launcher settings.
Conflicts between the game's renderer and modern display settings can lead to "soft locks" during dialogue: Deus ex human revolution dialogue crash fix
A common cause of freezing is how the game handles internal threading. If the game crashes on launch or during
Modern CPUs with many cores can cause the game to fail immediately or during heavy processing tasks. Deus ex human revolution dialogue crash fix
Open and navigate to HKEY_CURRENT_USER\Software\Eidos\Deus Ex: HRDC (or Deus Ex: HR for the standard version). Find AllowJobStealing and set it to 0 .