Atopy

The core of atopy is a Type I hypersensitivity reaction driven by a Type 2 immune response.

: These cells produce cytokines (IL-4, IL-13) that trigger B cells to differentiate into plasma cells producing allergen-specific IgE. The core of atopy is a Type I

: Upon re-exposure, allergens cross-link IgE on the surface of mast cells, causing degranulation and the release of inflammatory mediators like histamine and leukotrienes. 2. The Atopic March activating TH2 or ILC2 cells.

While there is currently no cure, management focuses on controlling inflammation and restoring barrier function. Atopy - StatPearls - NCBI Bookshelf - NIH The core of atopy is a Type I

: Antigen-presenting cells perceive allergens (like pollen or dust mites) as danger signals, activating TH2 or ILC2 cells.