: Polyene drugs act directly on the fungal cell membrane by binding to ergosterol.
: Fluconazole , itraconazole , and voriconazole . 2. Polyenes antifungal agent
-(1,3)-D-glucan, a major polysaccharide responsible for maintaining the structural integrity of the cell wall, causing cell lysis. : Polyene drugs act directly on the fungal
: Allylamines inhibit the enzyme squalene epoxidase. Common Examples : Terbinafine
: This blocks an early step in ergosterol biosynthesis, leading to a toxic buildup of squalene and depletion of ergosterol. Common Examples : Terbinafine. Antifungal Agents - StatPearls - NCBI Bookshelf - NIH
To combat fungal infections safely, medical science targets biological structures and pathways that are unique to fungi. Modern antifungal agents are primarily categorized into four major classes based on their specific mechanisms:
: Caspofungin , micafungin, and anidulafungin. 4. Allylamines