Akari Yamazaki May 2026

A significant portion of her co-authored work focuses on the apolipoprotein E (APOE) gene—specifically the ε4 allele, which is the strongest genetic risk factor for Alzheimer's disease.

In the physical sciences, Akari Yamazaki is a talented chemist at Shinshu University in Japan, working heavily within the Graduate School of Science and Technology. Her work leans toward the synthesis, reactivity, and properties of non-benzenoid aromatic compounds. Exploring Azulene Derivatives akari yamazaki

: Her research published in journals like Arteriosclerosis, Thrombosis, and Vascular Biology has demonstrated that ApoE in Brain Pericytes regulates endothelial cell phenotype. This showed that ApoE4 impairs the basement membrane formation of capillaries, contributing to cognitive decline. A significant portion of her co-authored work focuses

This technique was detailed in the established protocol paper featured in STAR Protocols , which allows researchers to execute high sequencing depth of mouse brain vascular cells to study brain diseases. The Role of ApoE4 and Cerebrovascular Function Exploring Azulene Derivatives : Her research published in

She established highly specialized cell isolation procedures to secure glio-vascular cell-enriched single-cell suspensions.

One of Yamazaki’s most notable technical contributions to the scientific community is her work on profiling the transcriptomics of the blood-brain barrier.