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: Data demonstrating that novel compounds targeting this site effectively lower blood pressure. 5. Discussion and Conclusion

: Evidence that oxidant-induced PKG Iα disulfide formation occurs in vivo during hypertension. 23484.rar

: Protein Kinase G Iα (PKG Iα) is usually activated by cGMP, but it can also be activated by "oxidative stress" (specifically the formation of a disulfide bond at Cys42). : Data demonstrating that novel compounds targeting this

: Western immunoblotting to detect the redox state of PKG and phosphorylation levels. 4. Results : Protein Kinase G Iα (PKG Iα) is

: Targeting the Oxidative Activation of Protein Kinase G Iα: A Novel Therapeutic Approach for Hypertension.

: Measurement of blood pressure in conscious, freely moving mice using telemetric probe catheters .

: To prove that preventing or reversing this oxidative activation can lower blood pressure. 3. Methods (Key Techniques)